Tyler Cowen gives us his list. The only one I have read, Max Hastings' Winston Churchill's War, I found not so interesting. In fact, the 2010 crop of books did not produce many keepers, from my perspective.
Matt Ridley's The Rational Optimist is still at the top of my chart. Clearly, Tyler sees it differently.
I am still only about 1/4 through Kevin Kelly's What Technology Wants, but at this point it is number two. I am not saying you have to buy into his main theme, but there are enough interesting observations to make it worthwhile.
I am going to put All the Devils are Here, the financial crisis book by Joe Nocera and Bethany McLean, at number 3. One of my fantasy dialogues is with someone who asks me why, given that I worked for Freddie Mac, I think that securitization needs to be killed (or government support for it withdrawn, which is the same thing). My answer would be to say "Read this book first, and then let's discuss." I would say the same thing if somebody were to ask me, "What is public choice theory in economics, and why is it important?"
Overall, I think it was a better year for essays than for books. My guess is that David Brooks, who annually gives his opinion of the best essays, will not have a difficult time producing his list for this year.